Negative feedback (HT only) (4.5.3.7) — AQA GCSE Biology Revision Notes

Revision notes for AQA GCSE Biology specification point 4.5.3.7, Negative feedback (HT only).

Adrenaline and Thyroxine

ADRENALINE:

ADRENALINE is a hormone released by the ADRENAL GLANDS, which sit on top the KIDNEYS.

Triggered by stress, fear, or a threat, ADRENALINE gets the body ready for quick action by using the 'FIGHT OR FLIGHT' response.

ADRENALINE causes:

  • INCREASES HEART RATE: To supply muscles and organs with more OXYGEN.
  • BOOSTS ENERGY SUPPLY: By increasing GLUCOSE LEVELS in the blood, providing immediate energy for the BRAIN and MUSCLES.

 

THYROXINE:

THYROXINE, secreted by the THYROID GLAND located in the NECK, is essential for normal growth, development, and metabolism. 

 

It specifically influences:

  • BASAL METABOLIC RATE (BMR): Determines how fast the body uses energy at rest.

 

It is regulated by THYROID-STIMULATING HORMONE (TSH) which is released by the PITUITARY GLAND.

  • When TSH is RELEASED, the thyroid gland RELEASES thyroxine.
  • When TSH is INHIBITED (stopped), the thyroid gland STOPS RELEASING thyroxine.

 

 Negative Feedback

  • TSH itself is regulated by a NEGATIVE FEEDBACK mechanism, ensuring thyroxine levels remain balanced.
  • The NEGATIVE FEEDBACK system in the body works similarly to a thermostat, adjusting hormone levels to keep them within a healthy range.
  • This system prevents the overproduction or underproduction of hormones, maintaining HOMEOSTASIS.

 Thyroxine Graph

  • When THYROXINE levels are too HIGH, TSH release is REDUCED to lower production.
  • Conversely, if THYROXINE levels are too LOW, TSH production is INCREASED to stimulate more thyroxine release.

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